Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 40, 2010 - Issue 5
92
Views
4
CrossRef citations to date
0
Altmetric
Clinical Pharmacokinetics and Metabolism

Pharmacokinetics of antofloxacin hydrochloride, a novel fluoroquinolone, after single-dose intravenous administration in healthy Chinese male volunteers

, , , , , , , & show all
Pages 344-349 | Received 07 Dec 2009, Accepted 25 Jan 2010, Published online: 15 Mar 2010
 

Abstract

  1. The purpose of the study was to evaluate the pharmacokinetic characteristics of a single, intravenous dose of antofloxacin hydrochloride in healthy Chinese male volunteers.

  2. Twelve subjects were randomly assigned to groups that received a single, intravenous dose of 200, 300, or 400 mg antofloxacin hydrochloride in a three-way crossover design study. The serum and urine concentrations of antofloxacin were then assayed with high-performance liquid chromatography (HPLC). Major pharmacokinetic parameters and urine excretion were obtained up to 96 h after administration.

  3. All three dosages were well tolerated. No clinically adverse reactions or abnormal laboratory results were detected.

  4. After single-dose intravenous administration, antofloxacin hydrochloride exhibited linear pharmacokinetic characteristics with increasing dosages. The Cmax for groups treated with 200, 300, or 400 mg dosages were 2.05 ± 0.38, 3.01 ± 0.60, and 3.80 ± 0.78 mg l−1, respectively; the areas under the curve from zero to infinity (AUC0–∞) were 25.14 ± 2.95, 37.63 ± 5.42, and 53.87 ± 9.48 mg l−1·h, respectively. The t1/2β was around 20 h; and the urinary excretion was measured as being from 58% to 60% within 96 h.

  5. Based on these results, 300 mg of antofloxacin hydrochloride administered once daily is the dose suggested for further investigation in multiple-dose administration studies.

Acknowledgements

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 897.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.