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Xenobiotica
the fate of foreign compounds in biological systems
Volume 43, 2013 - Issue 1
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Review Article

Up-regulation of cytochrome P450 and phase II enzymes by xenobiotics in precision-cut tissue slices

Pages 15-28 | Received 15 May 2012, Accepted 28 May 2012, Published online: 28 Jun 2012
 

Abstract

  1. Induction of the drug-metabolising enzyme systems is a major cause of clinically relevant drug interactions. The potential of a drug to engage in such interactions may be assessed in in vitro systems such as precision-cut tissue slices.

  2. Precision-cut tissue slices have a number of important advantages compared with the use of cells in culture, especially when tissues with a heterogeneous cellular population are concerned.

  3. Extensive studies concerned with the induction of cytochrome P450 and Phase II enzymes in precision-cut tissue slices from various animal and human tissues, such as liver, lung and intestine, using established inducing agents have revealed that slices mimic the in vivo situation.

  4. Precision-cut tissue slices is a reliable, informative and cost-effective technique for assessing the potential of chemicals to up-regulate drug-metabolising enzyme systems.

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