Drug peptide conjugates in human urine?

Abstract

1. Once in a while, during drug metabolism studies, an unusual or unexpected pathway is unearthed.

2. Such quirky finds open a refreshing hiatus, providing a departure from the, perhaps now mundane, textbook routes.

3. This brief missive draws attention to an interesting anecdote that may be unknown to some and concerns a substituted thioxanthenone drug.

• Amino acid
• hycanthone
• lucanthone
• peptide conjugates
• sulphoxide

Acknowledgements

The authors would like to thank Mr J. O’Gorman for assistance with the synthesis of lucanthone hydrochloride and Dr J. E. Fox of Alta Bioscience for analyses of the urine samples.