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Xenobiotica
the fate of foreign compounds in biological systems
Volume 44, 2014 - Issue 8
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Research Article

Glucuronidation of aurantio-obtusin: identification of human UDP-glucuronosyltransferases and species differences

Bao-Li MiPharmaceutical College, Liaoning University of Traditional Chinese Medicine DalianChina
,
Qi SunResearch and Development Department, JiLin Aodong Medicine Industry Group Co., Ltd. DunhuaChina
,
Yan-Qing QuThyroid Surgery, Yantaishan Hospital, Yantai ShandongChina
,
Xiao-Xu GaoPharmaceutical College, Liaoning University of Traditional Chinese Medicine DalianChina
,
Zhen-Wen YuPharmaceutical College, Liaoning University of Traditional Chinese Medicine DalianChina
,
Guang-Bo GeLaboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences DalianChina
,
Shan-Shan CaiPharmaceutical College, Liaoning University of Traditional Chinese Medicine DalianChina
,
Jie ZhangPharmaceutical College, Liaoning University of Traditional Chinese Medicine DalianChina
,
Yan-Chao ZhengPharmaceutical College, Liaoning University of Traditional Chinese Medicine DalianChina
&
Zhen-Qiu ZhangPharmaceutical College, Liaoning University of Traditional Chinese Medicine DalianChinaCorrespondence[email protected]
 show all
Pages 716-721 | Received 22 Jan 2014, Accepted 14 Feb 2014, Published online: 11 Mar 2014
 
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Abstract

1. The aurantio-obtusin’s glucuronide was detected when aurantio-obtusin was incubated with human liver microsomes (HLMs). Recombinant UGT isoforms screening experiment showed that UGT1A8 was the major isoform contributed to the glucuronidation.

2. The metabolic profiles for aurantio-obtusin in liver microsomes from different species were similar, however, the intrinsic clearance values (Vmax/Km) among the species were: Monkey > Human > Rat > Rabbit > Dog > Pig > Mouse > Guinea pig.

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