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Xenobiotica
the fate of foreign compounds in biological systems
Volume 46, 2016 - Issue 7
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Topics in Xenobiochemistry

The usefulness of Øie–Tozer’s model in deriving pharmacokinetic changes in response to changes in the concentration of drug-binding plasma protein

Pages 659-663 | Received 18 Sep 2015, Accepted 03 Oct 2015, Published online: 02 Nov 2015
 

Abstract

1. Øie–Tozer’s model can be used to derive changes in the distribution of drugs in relation to changes in the concentration of drug binding plasma proteins.

2. Concerns have been raised that the model is invalid for this purpose because it does not account for active drug transport, pH differences between fluids and extracellular tissue binding.

3. Here, it is demonstrated that these imperfections do not affect the outcome of the calculation.

Declaration of interest

The author has no conflict of interest to declare.

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