Techniques for Assessment of Biliary Excretion and Enterohepatic Circulation in the Rat

Abstract

1. A surgical technique is described which enables biliary excretion studies to be performed in conscious unrestrained rats.

2. Bile is continuously collected in a glass vessel implanted into the peritoneal cavity.

3. Assessment of enterohepatic circulation is made by a modification of the technique.

4. The application of these techniques to both metabolic and pharmacokinetic studies is described briefly.