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Abstract
1. The excretion of proxicromil and its metabolites into the milk of nursing rat mothers and its ingestion by rat pups have been investigated.
2. The methodology employed, hand-milking of the mothers and analysis of suckling rat pups or their stomach contents, has been developed from a review of the scientific literature. The most dependable of the methods used was the analysis of the stomachs of suckling rat pups. This method provided a useful index of radioactivity excreted into milk and allowed calculation of neonate exposure.
3. At a maternal dose level of 20mg/kg a significant proportion of the dose (1-2%) was excreted into the milk. Analysis of milk taken from rat pup stomachs indicated that both proxicromil (63%) and its hydroxylated metabolites (37%) were present in the milk.