3-Thiomethylparacetamol sulphate and glucuronide: metabolites of paracetamol and N-hydroxyparacetamol

S. J. Hart Department of Organic Chemistry, University of Melbourne, Parkville, 3052, Australia

K. Healey Department of Organic Chemistry, University of Melbourne, Parkville, 3052, Australia

M. C. Smail Department of Organic Chemistry, University of Melbourne, Parkville, 3052, Australia

I. C. Calder Department of Organic Chemistry, University of Melbourne, Parkville, 3052, Australia

Abstract

1. Two new metabolites of paracetamol, 3-thiomethylparacetamol sulphate and glucuronide, have been isolated and identified.

2. The metabolites occurred in both rat and mouse urine after administration of either paracetamol of N-hydroxyparacetamol. The amount excreted increased proportionally with the dose.

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3-Thiomethylparacetamol sulphate and glucuronide: metabolites of paracetamol and N-hydroxyparacetamol

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3-Thiomethylparacetamol sulphate and glucuronide: metabolites of paracetamol and N-hydroxyparacetamol

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