Abstract
1. The α-C-oxidation of N-ethyl-N-methylaniline and of the 4-chloro and 4-methyl derivatives was inhibited by SKF-525A, DPEA, carbon monoxide and cyanide and induced by phenobarbitone but not by 3-methylcholanthrene pretreatment.
2. The N-oxidation of these tertiary anilines was not influenced by SKF-525A, carbon monoxide or cyanide, nor by phenobarbitone or 3-methylcholanthrene pretreatment.
3. The N-oxidase was activated by DPEA and n-octylamine and inhibited by 1-naphthylthiourea.
4. The evidence indicates that metabolic α-C-oxidation of these substrates is mediated by a cytochrome P-450-dependent pathway whilst N-oxidation is mediated by a flavo-protein amine oxidase.