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Xenobiotica
the fate of foreign compounds in biological systems
Volume 16, 1986 - Issue 1
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Original Article

Dihydrochalcone metabolism in the rat: trihydroxylated derivatives related to phloretin

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Pages 35-45 | Received 24 Jan 1985, Published online: 30 Sep 2009
 

Abstract

1. The metabolism of 2′,4′,4-, 2′,6′,3- and 2′,6′,4-trihydroxydihydrochalcone was studied in rats

2. Approx. 25–35% of the oral-dose (0.75 mmol/kg) was excreted in the urine during a five to six day period.

3. The unchanged compounds were the most prominent urinary excretion products and were also present in large amounts in the faeces.

4. Other metabolites of the three dihydrochalcones included minor amounts of hydroxylated products and subsequent O-methylated derivatives as well as minor amounts of degradation products (resorcinol and hydroxyphenylpropionic acids) arising from scission of the compounds by the normal gut microflora.

5. The present results support the view that the degradative metabolism of dihydrochalcones involves scission leading to equal amounts of products derived from the A- and B-ring regions of these flavonoids.

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