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Xenobiotica
the fate of foreign compounds in biological systems
Volume 16, 1986 - Issue 3
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Research Article

Chlorinated paraffins: formation of sulphur-containing metabolites of polychlorohexadecane in rats

, , , &
Pages 225-232 | Received 01 May 1985, Published online: 22 Sep 2008
 

Abstract

1. A uniformly 14C-labelled polychlorinated hexadecane (14C-PCHD; 65% chlorine by wt) was injected into the portal vein in bile duct-cannulated rats (5–6 mg/kg) and the bile was collected for two or three days.

2. Less than 3% of the total amount of radioactivity excreted in the bile was due to unchanged 14C-PCHD. The radioactivity was separated by ion-exchange chromatography into two major fractions: one acidic, the other amphoteric. Comparison with a similar fractionation of propachlor metabolites indicates that the fractions contain 14C-PCHD conjugates of N-acetylcysteine (mercapturic acid) and glutathione, respectively.

3. The tentative 14C-PCHD-mercapturic acid on t.l.c. had an RF value similar to that of a synthetic PCHD-mercapturic acid, and chlorine and divalent sulphur were shown to be present.

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