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Xenobiotica
the fate of foreign compounds in biological systems
Volume 17, 1987 - Issue 4
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Original Article

Effects of antibiotic pretreatments on the metabolism and excretion of [U14C](+)-catechin ([U14C](+)-cyanidanol-3) and its metabolite, 3′-0-methyl-(+)-catechin

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Pages 423-434 | Received 15 Dec 1985, Published online: 30 Sep 2009
 

Abstract

1. Antibiotic pretreatment significantly altered metabolism of (+)-catechin (cyanidanol-3) in the rat, with decreases in both the urinary elimination of flavanol conjugates and of ring scission of the O-heterocyclic aglycone.

2. The majority of the β-glucuronidase(s) active in the degradation of flavanol conjugates is associated with the anaerobic microflora of the rat intestine.

3. Ring scission is a minor reaction in vivo and appears to be due to anaerobic bacteria, although in vitro it is the major reaction and is promoted by both anaerobes and aerobes.

4. The intestinal microflora are capable of demethylating the metabolite 3′-O-methyl-(+)-catechin in vivo; the major activity being associated with the aerobic microflora.

5. Faecal elimination of unchanged (+)-catechin is of minor importance.

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