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Abstract
1. The metabolism of stobadine, a γ-carboline antiarrhythmic and cardioprotective agent, was investigated in vitro using fortified rat liver microsomal preparations.
2. Two metabolic products, N-desmethyl stobadine and stobadine N-oxide were isolated and identified by means of t.l.c., g.l.c.-mass spectrometry, n.m.r. spectrometry and comparison with synthetic reference compounds.
3. Stobadine N-oxide was resolved into two optically active stereoisomers which were produced enzymically in approximately equal quantities.