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Abstract
1. An h.p.l.c. method has been developed to quantify the GSH conjugate of 1,3-dichloropropene (DCP).
2. The GSH conjugate of DCP (GSCP) was detected in the blood of rats exposed to DCP by inhalation, and elimination of GSCP from rat blood fitted a one-compartment model.
3. Exposure of rats to 78, 155, or 404 ppm DCP gave an elimination t1/2 of 17 h, independent of exposure concentration.