Aminopyrine infusion breath test for the determination of changes in P450 metabolism in vivo

S. K. Kuwahara Committee on Clinical Pharmacology, Department of Pharmacology and Physiological Sciences and Medicine, University of Chicago, 947 East 58th Street, Chicago, IL, 32, USA; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT, 32, USA

T. J. Shinn Committee on Clinical Pharmacology, Department of Pharmacology and Physiological Sciences and Medicine, University of Chicago, 947 East 58th Street, Chicago, IL, 32, USA

B. D. Schreider Committee on Clinical Pharmacology, Department of Pharmacology and Physiological Sciences and Medicine, University of Chicago, 947 East 58th Street, Chicago, IL, 32, USA

M. L. Phan Committee on Clinical Pharmacology, Department of Pharmacology and Physiological Sciences and Medicine, University of Chicago, 947 East 58th Street, Chicago, IL, 32, USA

A. N. Kotake Committee on Clinical Pharmacology, Department of Pharmacology and Physiological Sciences and Medicine, University of Chicago, 947 East 58th Street, Chicago, IL, 32, USA

Abstract

1. An osmotic mini-pump was used to maintain a constant infusion of radiolabelled [N-dimethyl-¹⁴C] aminopyrine into a rat. After implanting the mini-pump, ¹⁴CO₂ expiration rate was constant within 12h, and this rate was maintained for 192 h.

2. Treatment with 2-diethylaminoethyl-2,2-diphenylvalerate HCl (SKF 525-A) or cimetidine, inhibitors of P450-dependent metabolism, resulted in both dose- and time-dependent inhibition of the expiration of ¹⁴CO₂.

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Aminopyrine infusion breath test for the determination of changes in P450 metabolism in vivo

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Aminopyrine infusion breath test for the determination of changes in P450 metabolism in vivo

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