Papillary thyroid cancer arising in struma ovarii

Abstract

Malignant struma ovarii is a rare clinical entity that poses a therapeutic challenge, as there is no ‘gold standard’ of care. We aimed to develop evaluation and treatment guidelines by reviewing presentation and outcomes of the available literature. We present a 60-year-old female with papillary thyroid carcinoma arising in a mature teratoma, and our multidisciplinary approach to care and follow-up. We examined 59 cases for characteristics, including rates of metastasis and recurrence, and response to surgical and adjuvant treatment. We found higher rates of metastasis and recurrence than traditionally reported, and found no recurrence in patients treated with oophorectomy, thyroidectomy, and I-131 radioablation. A multimodal approach to the treatment of malignant struma ovarii may improve survival and decrease risk of recurrence.

Keywords::

• Ovarian cancer
• papillary thyroid carcinoma
• struma ovarii
• treatment

Acknowledgement

This work was supported by the Reproductive Scientist Development Program through NIH grant #5K12HD00849-23 for Dr. Tanyi.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.