Homocysteine, folate and pregnancy outcomes

Abstract

The purpose of this study is to evaluate the relationship between maternal and/or cord blood folate/homocysteine concentrations and adverse pregnancy outcomes. The study population included a random sample of singleton pregnant women in whom we measured total homocysteine and folic acid in maternal or cord blood at deliveries. A total of 227 pregnant women were enrolled. The concentration of folate in maternal blood tended to be significantly lower in pre-term birth than in full-term delivery group (median (95% CI), 14.4 (3.6–73) vs 25 (7.3–105.5) p < 0.01). The total homocysteine in maternal and cord blood was significantly higher in the pre-eclampsia than in the normotensive group (7.9 (1.7–28.2) vs 5.9 (1.8–14.6) μmol/ml, p < 0.05; and 5.8 (2.6–14.4) vs 4.2 (0.7–7.9) ng/ml, p < 0.05, respectively). Lower maternal serum folate concentration is associated with pre-term delivery and higher maternal plasma homocysteine concentration with pre-eclampsia.

Keywords::

• Folate
• homocysteine
• pregnancy outcomes
• pre-term delivery

Acknowledgements

This study was supported by grant No. K1031741 from Korea University College of Medicine and a grant (A090858) of Health Care Research and Development Project, Ministry of Health and Welfare, Republic of Korea. No support was received from any pharmaceutical company.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.