Serum sirtuin 1 levels in patients with polycystic ovary syndrome

Abstract

Objective of the study is to determine the human nicotinamide adenine dinucleotide-dependent deacetylase sirtuin 1 level in women with polycystic ovary syndrome (PCOS). This cross-sectional study included 24 patients aged 20–38 years, who were diagnosed to have PCOS (patient group). The control group included 16 age- and body mass index-matched healthy female volunteers. The patients and controls were compared in terms of pre-prandial blood glucose, the homoeostatic model assessment for insulin resistance (HOMA-IR) index, and cholesterol, triglyceride, high-density lipoprotein (HDL), low-density lipoprotein (LDL), C-reactive protein (CRP) and sirtuin 1 levels.

The mean sirtuin 1 level in the patient group (6.67 ± 2.29 ng mL^–1) was significantly higher than that in the control group (4.69 ± 1.85 ng mL^–1) (P = 0.007). Correlation analysis showed that there were no significant differences between the groups in fasting blood glucose, HOMA-IR index or cholesterol, triglyceride, HD, LDL and CRP levels.

The sirtuin 1 level, which is associated with inflammation, the immune system and insulin metabolism, was higher in the PCOS patients than in the healthy controls.

Keywords::

• PCOS
• sirtuin 1

Declaration of interest: The authors report they have no conflicts of interest financial or otherwise related to the materials presented herein.