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Review Article

Molecular mechanisms of paraquat-induced acute lung injury: a current review

, &
Pages 130-134 | Received 30 Mar 2013, Accepted 04 Jul 2013, Published online: 07 Jan 2014
 

Abstract

Paraquat is an organic heterocyclic herbicide that is widely used in agriculture, especially in Asian countries. The prevalence of paraquat poisonings has increased dramatically in the past two decades in China. Nearly all paraquat poisonings resulted from intentional or accidental oral administration leading to acute lung injury and, ultimately, acute respiratory distress syndrome. The mortality rate has been reported to be greater than 90%. However, the exact toxic mechanism remains unclear. Herein, we reviewed and summarized the most recent publications related to the molecular mechanisms of paraquat-induced acute lung injury.

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