Induction of Testicular DNA Synthesis In Vitro by HCG and HMG Treatments in Men with Hypogonadotropic Hypogonadism

A. Okuyama Department of Urology and Pathology, Osaka University Medical School, Research Institute for Microbial Diseases, Osaka University, and the Department of Urology, Osaka-Central Hospital, Osaka, Japan

N. Nonomura Department of Urology and Pathology, Osaka University Medical School, Research Institute for Microbial Diseases, Osaka University, and the Department of Urology, Osaka-Central Hospital, Osaka, Japan

E. Koh Department of Urology and Pathology, Osaka University Medical School, Research Institute for Microbial Diseases, Osaka University, and the Department of Urology, Osaka-Central Hospital, Osaka, Japan

N. Kondoh Department of Urology and Pathology, Osaka University Medical School, Research Institute for Microbial Diseases, Osaka University, and the Department of Urology, Osaka-Central Hospital, Osaka, Japan

M. Nakamura Department of Urology and Pathology, Osaka University Medical School, Research Institute for Microbial Diseases, Osaka University, and the Department of Urology, Osaka-Central Hospital, Osaka, Japan

M. Namiki Department of Urology and Pathology, Osaka University Medical School, Research Institute for Microbial Diseases, Osaka University, and the Department of Urology, Osaka-Central Hospital, Osaka, Japan

H. Kiyohara Department of Urology and Pathology, Osaka University Medical School, Research Institute for Microbial Diseases, Osaka University, and the Department of Urology, Osaka-Central Hospital, Osaka, Japan

Y. Nishimune Department of Urology and Pathology, Osaka University Medical School, Research Institute for Microbial Diseases, Osaka University, and the Department of Urology, Osaka-Central Hospital, Osaka, Japan

K. Matsumoto Department of Urology and Pathology, Osaka University Medical School, Research Institute for Microbial Diseases, Osaka University, and the Department of Urology, Osaka-Central Hospital, Osaka, Japan

M. Matsuda Department of Urology and Pathology, Osaka University Medical School, Research Institute for Microbial Diseases, Osaka University, and the Department of Urology, Osaka-Central Hospital, Osaka, Japan

T. Sonoda Department of Urology and Pathology, Osaka University Medical School, Research Institute for Microbial Diseases, Osaka University, and the Department of Urology, Osaka-Central Hospital, Osaka, Japan

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Abstract

To study the effectiveness of hCG and hMG administration on spermatogenesis of patients with hypo-gonadotropic hypogonadism (HH), the DNA synthesis of spermatogonia was investigated by the method of ³H-thymidine uptake by cultured tissue fragments of human testis with or without treatment with hCG and/or hMG. Although in two groups treated with different concentrations of hCG the value of ³H-thymidine incorporation into testicular tissue showed no significant difference compared with the untreated control group, treatment with both hCG and hMG induced significant changes in the value of ³H-thymidine incorporation compared with the untreated control group. Combined hCG and hMG therapy was effective for induction of spermatogenesis in patients with HH.

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Induction of Testicular DNA Synthesis In Vitro by HCG and HMG Treatments in Men with Hypogonadotropic Hypogonadism

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Induction of Testicular DNA Synthesis In Vitro by HCG and HMG Treatments in Men with Hypogonadotropic Hypogonadism

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