Immunoglobulin G4-positive Sclerosing Idiopathic Orbital Inflammation: New Neuro-ophthalmological Presentations

Abstract

We report two rare cases of biopsy proven Immunoglobulin G4-related sclerosing orbital inflammation (IgG4SOI). The first case had intracranial involvement which, to our knowledge, is the first IgG4SOI case with serum cerebrospinal fluid abnormalities and the second case had an unusual presentation of a compressive optic neuropathy and systemic lymphadenopathy.

• Compressive optic neuropathy
• IgG4
• immunoglobulin G4-positive sclerosing idiopathic orbital inflammation
• immunoglobulin G4-positive with intracranial involvement
• sclerosing idiopathic orbital inflammation
• systemic lymphadenopathy

Declaration of Interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

This work was supported in part by an unrestricted grant from Research to Prevent Blindness, Inc. NY, NY. The authors have no conflicts of interest in this article to disclose.