Bilateral Optic Disc Swelling Following Anastrozole Therapy

Abstract

A 56-year-old female with early-stage breast cancer, stage IA grade 1 endometrial cancer, and stage IC grade 1 ovarian cancer developed sudden-onset visual changes and right inferior visual field defect following anastrozole therapy. Examination revealed severe bilateral optic disc swelling and impaired visual acuity. Laboratory work-up was otherwise unremarkable. Anastrozole was discontinued and over the next month, patient had near-complete resolution of swelling in the right eye and improvement in the left eye. This is the only reported case of optic disc swelling following anastrozole therapy.

• Breast neoplasms
• chemotherapy
• optical coherence tomography
• papilloedema
• vision

Declaration of interest: Dr. Bernard has served as a Consultant for Novartis and has received grant support from Biogen. The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

Note: Figure 1 of this article is available in colour online at http://informahealthcare.com/oph.