Abstract
This review article is dealing with the clinically relevant pupil research work, during the eighties and nineties and its consequences for the neuro-ophthalmologist. Suggestions for pupil examinations including pharmacological testing and handling of various pupillary disorders are given. The article covers the following items: (1) The pupil and the afferent visual system, (2) Parasympathetic pupillary dysfunction, (3) Disorders of the sympathetic pupillary innervation (Horners syndrome), (4) Other issues, including the pupil in diabetes mellitus, iris related pupillary disorders, the pupil as an indicator of vigilance, and the pupillary near reflex.