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The International Journal on Orbital Disorders, Oculoplastic and Lacrimal Surgery
Volume 30, 2011 - Issue 5
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Case Reports

Orbital Inflammation in IgG4-related Sclerosing Disease

, MD, , MD, , MD & , MD
Pages 258-260 | Received 27 Apr 2011, Accepted 29 May 2011, Published online: 29 Sep 2011
 

Abstract

IgG4-related sclerosing disease is a recently described systemic inflammatory disease that should be considered when evaluating patients with nonspecific orbital inflammation (pseudotumor). Orbital biopsy is necessary to establish a diagnosis and demonstrates lymphoplasmacytic infiltration, fibrosis, obliterative phlebitis of medium and small veins, and variable degrees of eosinophilia. We report the clinical and histopathological findings of 2 patients who developed chronic orbital inflammation as a manifestation of IgG4-related sclerosing disease. The 2 cases illustrate the widely varying clinical characteristics of this elusive disease.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

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