Abstract
Orbital fibroblasts play a key role in the pathogenesis of Graves’ ophthalmopathy (GO). We discuss some major aspects by which orbital fibroblasts contribute to GO and the important role of PDGF-BB herein. Finally, we propose the orbital fibroblast, and especially the PDGF system acting on orbital fibroblasts, as an important therapeutic target in GO.
ACKNOWLEDGEMENTS
This work was in part supported by the Stichting Wetenschappelijk Onderzoek Oogziekenhuis (SWOO 2007-01; LvS) and the Nederlandse vereniging van Graves’ patiënten (NVGP).
Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.