Banded Collagen in the Kidney with Special Reference to Collagenofibrotic Glomerulopathy

Abstract

Background: The normal glomerular basement membrane, composed of type IV collagen, plays an important function in the process of filtration. Rarely, type III, type I, or type V collagen is seen in the glomerulus, resulting in three different types of non-immune mediated glomerulopathies recognized thus far. These are characterized by deposition of banded collagen fibers in the glomerulus. Methods: The authors reviewed 4934 kidney biopsies submitted over the past 5 years. Five of these revealed the presence of banded collagen in the glomeruli. Conclusion: Combined clinical and ultrastructural examination has led to a definitive diagnosis. These diseases exhibit indolent progression and as yet do not have specific treatment.

Keywords:

• banded collagen
• collagenofibrotic glomerulopathy

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.