An Insight into Ultrastructural and Morphological Alterations of Platelets in Neurodegenerative Diseases

Abstract

Platelets are evinced as a systemic tool in a variety of disorders, including neurodegenerative diseases. Evidence suggests that variations in the ultrastructure and morphology of platelets and related organelles are involved in the pathophysiology of diabetes, cancer, HIV/AIDS, cardiovascular and neurological diseases. Due to structural alterations of platelets in many diseases, it is informative to discuss the ultrastructural and morphological discrepancies of platelets in contemporary medical research. The present review reveals the usefulness of ultrastructural study in better understanding of the disease patterns and may help to improve the treatment regimes.

Keywords:

• Electron microscopy
• Morphology
• Neurodegenerative diseases
• Platelets
• Ultrastructure

ACKNOWLEDGMENT

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.