Renal Giant Cytoplasmic Inclusions in Chédiak-Higashi Syndrome: First Ultrastructural Demonstration in a Human Biopsy

Abstract

This report ultrastructurally illustrates the giant lysosome-related organelles in the various cellular components of a renal biopsy from a 10 year-old female affected by the Chédiak-Higashi syndrome. Albeit similar observations have been made and reported in animal models of the syndrome, to the author’s knowledge, this is the first illustration of the changes as demonstrated in a human renal biopsy.

Keywords:

• Chédiak-Higashi
• Megalysosome
• Kidney
• Ultrastructure
• Human

ACKNOWLEDGMENT

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.