Electron Microscopy Remains the Gold Standard for the Diagnosis of Epithelial Malignant Mesothelioma: A Case Study

Abstract

This is a case of idiopathic epithelial malignant mesothelioma in a 47-year-old mechanic. The advent of a large battery of immunochemical markers has provided new tools for the diagnosis of mesothelioma in recent years; however, immunostaining can often be misleading or inconsistent, as demonstrated in this case. This report highlights the lasting utility of electron microscopy in the diagnosis of mesothelioma. Ultrastructural features of epithelial mesothelioma were discernable using electron microscopy even on somewhat poorly preserved chest wall biopsy specimens from paraffin blocks. These images, combined with immunostains and a fiber analysis from the lungs, allowed for a final diagnosis of a non-asbestos-related malignant epithelial mesothelioma in this patient.

• Electron microscopy
• epithelial malignant mesothelioma
• renal cell carcinoma
• tremolite cleavage fragment

DECLARATION OF INTERESt

T. D. O. serves as a consultant on medical–legal cases involving asbestos-associated diseases.

E. A. O. is funded by the Angiopathy Training Grant (T32 HL094295) and NRSA 1F30ES024045.