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An islet cell tumor of the pancreas with unusual light microscopic, ultrastructural, and immunocyto-chemical features is reported. In addition to secretory granules and positive immunostaining for pancreatic polypeptide, the tumor contained globoid intracytoplasmic inclusions by light and electron microscopy, which correlated with a positive immunoreaction for alpha-1-antitrypsin, and Reinkelike crystals.
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