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Journal of Microencapsulation
Micro and Nano Carriers
Volume 26, 2009 - Issue 7
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Original

Preparation and characteristics of chitosan microspheres in different acetylation as drug carrier system

Ai Hong Wang College of Marine Life Science, Ocean University of China, Qingdao, PR China
,
Xi Guang Chen College of Marine Life Science, Ocean University of China, Qingdao, PR ChinaCorrespondence[email protected]
,
Cheng Sheng Liu College of Marine Life Science, Ocean University of China, Qingdao, PR China
,
Xiang Hong Meng College of Marine Life Science, Ocean University of China, Qingdao, PR China
,
Le Jun Yu College of Marine Life Science, Ocean University of China, Qingdao, PR China
&
Hua Wang State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai, PR China
Pages 593-602 | Received 06 Oct 2008, Accepted 27 Oct 2008, Published online: 05 Nov 2009
 
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Abstract

Chitosan microspheres (CM) and reacetylated chitosan microspheres (ACM) were successfully made by the methods of oil/water emulsification and acetic anhydride. The characteristics of the microspheres as a drug carrier system were investigated. Two microsphere samples had spherical shape with the mean diameter of 80.79 µm for CM and 81.25 µm for ACM. The in vitro degradation (pH 7.4) in the presence of lysozyme showed a slow mass loss and ACM was higher degradation compared to CM. The microspheres, especially ACM, had a high drug loading capacity of Adriamycin hydrochloride (ADM) (12.4%) and had sustained release. The cytotoxicity was evaluated in vitro via MTT assay, ACM with steadily continual adhesion to cells had no fibroblast cytotoxicity. The inhibitory rates of ADM-loading CM, ACM suspension to Tca 8113 cells were significantly outperformed that of ADM solution.

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