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Research Article

A new hydrogel drug delivery system based on Hydroxyethylstarch derivatives

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Pages 400-408 | Received 21 Apr 2009, Accepted 27 Sep 2009, Published online: 03 Nov 2009
 

Abstract

A new method has been developed to produce a drug delivery system (DDS) for proteins and peptides. Employing a water-in-water emulsion technique with polyethylenglycol and hydroxyethylstarch substituted by hydroxyethylmethacrylate and a subsequent photopolymerization, microspheres can be produced. This process can be carried out with proteins present in the cross-linkable phase and without the need of any organic solvents. The hydrogel microparticles are promising to fulfil the requirements for a DDS regarding biocompatibility and biodegradability.

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