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Research Article

Encapsulation of podophyllotoxin and etoposide in biodegradable poly-d,l-lactide nanoparticles improved their anticancer activity

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Pages 211-219 | Received 10 Oct 2012, Accepted 25 Jul 2013, Published online: 09 Oct 2013
 

Abstract

To improve the efficacy podophyllotoxin (PODO) and etoposide (ETOPO) were encapsulated in poly-d,l-lactide nanoparticles (PLA NPs). The size of synthesised PODO-loaded PLA NPs and ETOPO-loaded PLA NPs was 100 ± 17 nm and 163 ± 20 nm and their encapsulation efficiency was 17 and 48%, respectively. In vitro release studies showed initial burst release followed by slow and sustained release. In vitro cytotoxicity of synthesised NPs was assessed using A549 and CHO-K1 cells. Blank PLA NPs did not show any toxicity. While PODO-loaded PLA NPs showed higher in vitro cytotoxicity in comparison to ETOPO-loaded PLA NPs against both cell lines. Also, the cytotoxicity of both PODO-loaded PLA NPs and ETOPO-loaded PLA NPs was higher compared to pure drugs. Hence, this study documents the improvement in efficacy of these molecules upon encapsulation in PLA NPs and could be an important strategy for better therapeutics.

Acknowledgements

Authors are thankful to the Director, CSIR-IHBT, Palampur, for continuous support and encouragment. The CSIR-IHBT communication number of this article is 3404.

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