Design and evaluation of mucoadhesive beads of glipizide as a controlled release drug delivery system

Abstract

The present work aims at the development of a low-cost controlled release system of glipizide beads embedded in pectin to overcome the problem of frequent dosing of drug. The method of preparation has been optimised by experimental design to achieve satisfactory responses with respect to controlling variables. The controlling variables are X₁, drug–polymer ratio; X₂, surfactant concentration and X₃, isooctane–acetone ratio. The most effective combination is X₁(1:6), X₂(1%), X₃(50:50). Various parameters such as mucoadhesivity and swellability of beads, characterisation, dissolution, stability, ex vivo absorption and in vivo (Oral glucose tolerance test in rat) studies were performed with the optimised product. The optimised product was found quiet satisfactory that showed yield of 86.78%, drug entrapment efficiency (DEE) of 87.38% and drug release was extended up to 18 h. The present formulation of glipizide is a promising multiparticulate system of glipizide with significant hypoglycemic effect, and moreover it was prepared rapidly with ease.

• Experimental design
• glipizide
• hypoglycemic
• mucoadhesion
• pectin

Acknowledgements

The authors acknowledge the cooperation provided by “Calcutta Institute of Pharmaceutical Technology & AHS”, Uluberia, West Bengal, India. The authors are thankful to Mr N. Gani who helped in making of the manuscript.