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Journal of Microencapsulation
Micro and Nano Carriers
Volume 31, 2014 - Issue 5
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Research Article

Evaluation of anticancer activity of celastrol liposomes in prostate cancer cells

Joy WolframDepartment of Nanomedicine, Houston Methodist Research Institute Houston, TXUSA;CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience & Technology of China BeijingChina
,
Krishna SuriDepartment of Nanomedicine, Houston Methodist Research Institute Houston, TXUSA
,
Yi HuangDepartment of Nanomedicine, Houston Methodist Research Institute Houston, TXUSA
,
Roberto MolinaroDepartment of Nanomedicine, Houston Methodist Research Institute Houston, TXUSA;Department of Health Science, University Magna Græcia of Catanzaro GermanetoItaly
,
Carlotta BorsoiDepartment of Nanomedicine, Houston Methodist Research Institute Houston, TXUSA
,
Bronwyn ScottDepartment of Nanomedicine, Houston Methodist Research Institute Houston, TXUSA
,
Kathryn BoomDepartment of Nanomedicine, Houston Methodist Research Institute Houston, TXUSA
,
Donatella PaolinoDepartment of Health Science, University Magna Græcia of Catanzaro GermanetoItaly
,
Massimo FrestaDepartment of Health Science, University Magna Græcia of Catanzaro GermanetoItaly
,
Jianghua WangDepartment of Pathology and Immunology, Baylor College of Medicine Houston, TXUSA
,
Mauro FerrariDepartment of Nanomedicine, Houston Methodist Research Institute Houston, TXUSA;Department of Medicine, Weill Cornell Medical College Manhattan, New York, NYUSA
,
Christian CeliaDepartment of Nanomedicine, Houston Methodist Research Institute Houston, TXUSA;Department of Pharmacy, University G. d Annunzio of Chieti Pescara, ChietiItaly
&
Haifa ShenDepartment of Nanomedicine, Houston Methodist Research Institute Houston, TXUSA;Department of Cell and Developmental Biology, Weill Cornell Medical College Manhattan, New York, NYUSACorrespondence[email protected]
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Pages 501-507 | Received 13 Sep 2013, Accepted 23 Dec 2013, Published online: 24 Mar 2014
 
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Abstract

Context: Celastrol, a natural compound derived from the herb Tripterygium wilfordii, is known to have anticancer activity, but is not soluble in water. Objective: Formation of celastrol liposomes, to avoid the use of toxic solubilising agents. Materials and methods: Two different formulations of PEGylated celastrol liposomes were fabricated. Liposomal characteristics and serum stability were determined using dynamic light scattering. Drug entrapment efficacy and drug release were measured spectrophotometrically. Cellular internalisation and anticancer activity was measured in prostate cancer cells. Results: Liposomal celastrol displayed efficient serum stability, cellular internalisation and anticancer activity, comparable to that of the free drug reconstituted in dimethyl sulfoxide. Discussion and conclusion: Liposomal celastrol can decrease the viability of prostate cancer cells, while eliminating the need for toxic solubilising agents.

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