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Journal of Microencapsulation
Micro and Nano Carriers
Volume 33, 2016 - Issue 2
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Research Article

Preparation of magnetic and pH-responsive chitosan microcapsules via sonochemical method

Fengzhi XuCollege of Chemistry, Jilin University, Changchun, P. R. China;
,
Tianqi ZhaoCollege of Chemistry, Jilin University, Changchun, P. R. China;
,
Shurong WangDepartment of Ophthalmology, The Second Hospital of Jilin University, Changchun, P. R. China
,
Songfeng LiuCollege of Chemistry, Jilin University, Changchun, P. R. China;
,
Ting YangCollege of Chemistry, Jilin University, Changchun, P. R. China;
,
Zhanfeng LiCollege of Chemistry, Jilin University, Changchun, P. R. China;
,
Hongyan WangCollege of Chemistry, Jilin University, Changchun, P. R. China;
&
Xuejun CuiCollege of Chemistry, Jilin University, Changchun, P. R. China; Correspondence[email protected]
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Pages 191-198 | Received 01 Jul 2015, Accepted 05 Jan 2016, Published online: 18 Feb 2016
 
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Abstract

Magnetic and pH-responsive chitosan microcapsules (MPRCMCs) were prepared by a simple sonochemical method. Superparamagnetic oleic acid modified Fe3O4 nanoparticles (OA-Fe3O4 NPs) and hydrophobic drugs could be directly loaded into MPRCMCs during sonication. The obtained microcapsules had a well-defined spherical morphology with the average size of 2 μm. The microcapsules showed an excellent magnetic property. In addition, the pH-responsive controlled release of coumarin 6 (C6) from MPRCMCs indicated that the developed microcapsules could be a promising candidate for drugs carriers.

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