Pre-clinical evaluation of a microwave planar array applicator for superficial hyperthermia

Abstract

Multi-element hyperthermia applicators have an advantage over single-aperture devices in that the power deposition pattern across the applicator surface may be adjusted to improve the resultant temperature distribution. This capability can be used to compensate for irregular tumour geometry as well as heterogeneity of thermal and power absorption parameters within the tissue. This paper evaluates the first commercially available microwave system of this type designed for superficial hyperthermia. The applicator (16-element planar array, 915 MHz, 15·2 ± 15·2 cm footprint) was evaluated by the following: (1) measuring absolute SAR distributions in muscle-equivalent liquid phantom with an intervening 1 cm thick layer of fat phantom by scanning a calibrated E-field sensor, and (2) power output measurements using calorimetric methods. The SAR distributions measured for each individual aperture exhibited significant irregularities and differing power deposition patterns. A priori knowledge of these different power deposition characteristics was used to provide appropriate illumination schemes which could be used as initial starting points for producing clinically useful power deposition patterns. Measurements of these composite patterns demonstrate the adjustable nature and flexibility of the heating capabilities of this applicator, which includes 50% iso-SAR coverage that can be extended to the applicator perimeter. This clearly illustrates the clinical utility and potential advantages of this system over single-aperture devices for superficial hyperthermia.

Key Words:

• Hyperthermia
• microwave applicator
• SAR measurements
• microwave array
• calorimetric methods