The use of a reconstituted collagen foil dura mater substitute in paediatric neurosurgical procedures—Experience in 47 patients

Abstract

Background. CSF leakage is a common complication of neurosurgical procedures, with defective dural suture thought to be the most frequent cause. We report our experience with a new collagen foil (TissuDura®, Baxter Healthcare SA, Switzerland) utilized as dural substitute in paediatric neurosurgical procedures.

Methods. TissuDura® was used in children consecutively operated on at the department of paediatric neurosurgery, Catholic University, Rome, from March 2004 to August 2007. Children underwent surgical procedures in supratentorial, infratentorial and spinal compartments. In supratentorial and spinal procedures, the dural graft was used according to the overlay technique. In the posterior fossa procedures, the underlay technique was used.

Results. Forty-seven patients received TissuDura® during surgery. Thirty-one patients underwent surgery for the removal of posterior fossa tumours, nine for supratentorial tumours and seven for spinal dysraphisms. No CSF leakage was observed following the use of TissuDura® in supratentorial procedures. Two post-operative CSF leaks occurred in patients who had undergone spinal surgery. No post-operative hydrocephalus was noted in these two surgery groups. Three cases of CSF leakage occurred in patients who had undergone posterior cranial fossa surgery. All 3 cases had an associated supratentorial ventricular dilation present prior to the removal of the tumour (one case) or occurring after the tumour excision (two cases). No clinically evident adverse reactions directly related to TissuDura® were observed.

Conclusions. The main advantages of TissuDura® were its apparent ability to prevent CSF leakage when utilized in a specific subset of patients, and the absence of reactions or postoperative infections.

Key words:

• Dural substitute
• collagen
• CSF leakage
• duraplasty

Declaration of interest: The authors declare they have no financial interest in the material presented and discussed in the paper. The authors are responsible for the content and writing of the paper.