Clinical features and immunohistochemical expression levels of androgen, estrogen, progesterone and Ki-67 receptors in relationship with gross-total resected meningiomas relapse

Abstract

Objective. To investigate the recurrent risk factors of intracranial meningiomas after gross-total resection (Simpson蕅Grade). Methods. We retrospectively analysed 162 meningiomas in the General Hospital of Shenyang Military Region and Changzheng Hospital in Shanghai China, which underwent nearly gross-total resection using microneurosurgery techniques from 2002 to 2007. Monofactorial and Cox regression statistics methods were carried out to analyse the relationship between the post-operation tumour relapse and some clinical features including the patient sex, age, tumour size, tumour shape, tumour pathological grade and the immunohistochemical expression levels of Ki-67, androgen receptor (AR), estrogen receptor (ER) and progesterone receptor (PR). Results. There are 53 recurrent meningiomas during the follow-up period. The recurrent rate is about 32.7%. Immunohistochemistry results indicate that AR, ER, PR, Ki-67 are positively expressed on some tumour cell nuclear. Cox regression analysis reveals that tumour size, tumour shape, pathological grade and Ki-67 expression levels are significantly correlated with the tumour relapse (p <0.05). Conclusions. Our results demonstrate high recurrent rate for gross-total resection meningiomas. Tumour diameter exceeding 5 cm, irregular shape tumour, pathological grade II and III and positive expression of Ki-67 were the risk factors for post-operation meningioma relapse. The recurrent rate increases coincidentally with the follow-up period.

Keywords::

• meningioma
• operation
• prognosis
• immunohistochemistry

Acknowledgements

Writing of this paper would not have been possible without the help from many teachers and colleagues. In particular, we are indebted to Prof. Liu Huimin from the Pathological Department of Changzheng Hospital attached to the Second Military Medical University, Prof. Zhang Fulin from the Pathological Department of the Medical College, Fudan University and Prof. Yan Peisong from the Fourth Military Medical University, for their help in pathological diagnosis confirmation and IHC evaluation.

Declaration of interest: The authors report no conflicts of interests. The authors alone are responsible for the content and writing of the paper.