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Abstract
Primary objective: To study the protective effect of resveratrol on endotoxemia-induced neurotoxicity.
Methods: Rats were pre-treated during 7 days with 20 mg kg−1 body weight (b.w.) resveratrol and challenged with a single dose of lipopolysaccharide (LPS: 8 mg kg−1 b.w.) for 24 hours. Brains were harvested to determine LPS-induced lipoperoxidation level, antioxidant enzyme activities, nitric monoxide (NO) and iron distribution as well as the impact of resveratrol on these parameters.
Results: Resveratrol counteracted LPS-induced brain malondialdehyde (MDA) level and antioxidant enzyme activities depletion as superoxide dismutase (SOD), catalase (CAT) and peroxidase (POD). Resveratrol also reversed LPS-induced brain and plasma NO elevation as well as iron sequestration from plasma to brain compartment.
Conclusion: The data suggest that resveratrol is capable of alleviating LPS-induced neurotoxicity by a mechanism that may involve iron shuttling proteins.
| Abbreviations: | ||
| BHT | = | Butylated hydroxytoluene |
| CAT | = | Catalase |
| LPS | = | Lipopolysaccharide |
| MDA | = | Malondialdehyde |
| NO | = | Nitric oxide |
| NOS | = | Nitric oxide synthase |
| POD | = | Peroxidase |
| ROS | = | Reactive oxygen species |
| RVT | = | Resveratrol |
| SOD | = | Superoxide dismutase |
| TBA | = | Thiobarbituric acid |
| TCA | = | Trichloroacetic acid |
| Abbreviations: | ||
| BHT | = | Butylated hydroxytoluene |
| CAT | = | Catalase |
| LPS | = | Lipopolysaccharide |
| MDA | = | Malondialdehyde |
| NO | = | Nitric oxide |
| NOS | = | Nitric oxide synthase |
| POD | = | Peroxidase |
| ROS | = | Reactive oxygen species |
| RVT | = | Resveratrol |
| SOD | = | Superoxide dismutase |
| TBA | = | Thiobarbituric acid |
| TCA | = | Trichloroacetic acid |