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Abstract
We were pleased to read of Sloan and colleagues' experience with fluoxetine in treating emotional lability[1]. Their study supports our report of the efficacy of fluoxetine in the treatment of emotional incontinence in patients with stroke and multiple sclerosis [2]. We were also impressed, as was Sloan, by the relatively rapid onset of action of the drug. Patients responded within two to seven days, far sooner than the typical antidepressant effect of fluoxetine. This implies mechanisms of action different than the one by which fluoxetine relieves symptoms of depression. Further studies are warranted to elucidate these mechanisms.