Association Between SNPs (rs1533428, rs12994401, rs10202118) on chromosome 2p16.3 and primary open angle glaucoma

Abstract

Aims: A meta-analysis was conducted to evaluate the association of rs1533428, rs12994401, rs10202118 polymorphism on chromosome 2p16.3 with POAG susceptibility.

Methods: Systematic searches were performed on the electronic databases, the Cochrane Central Register of Controlled Trials, PubMed, ISI Web of Knowledge (Version 4.5), Chinese national knowledge infrastructure (CNKI), and Wanfang (Chinese) before March 2014. Overall and subgroup analyses were performed. Odds ratio (OR) and 95% confidence interval (CI) were used to evaluate the strength of associations. Heterogeneity and Sensitivity analysis was also performed.

Results: Seven published articles with 25 datasets were included in the meta-analysis. The overall results showed no evidence for significant association of rs1533428, rs12994401, rs10202118 polymorphism with POAG risk in allelic model (rs1533428: OR = 1.23 [1.01, 1.49], p = 0.03; rs12994401: OR = 1.32 [0.96, 1.81], p = 0.08; rs10202118: OR = 0.95 [0.76, 1.20], p = 0.68), and similar results were obtained in the dominant, additive and the recessive models and subgroup analysis based on the ethnicity.

Conclusions: Our study indicated that rs1533428, rs12994401, rs10202118 polymorphism on chromosome 2p16.3 might not be a risk factor for POAG. Further studies with well-designed among different ethnicity populations are required.

• 2p16.3
• chromosome 2p
• meta-analysis
• primary open angle glaucoma
• polymorphism

Acknowledgements

The authors thank the authors whose studies were involved in this meta-analysis and provided useful data to us.

Declaration of interest

The authors of this study indicate no financial conflict of interest. No current external funding sources for this study