Amyloid β Peptides and Cognitive Functions in Patients with Pseudoexfoliation Syndrome

Abstract

Purpose: The aim of this study was to evaluate if there is any relation between the Alzheimer’s peptides (amyloid β-40 and β-42) concentration in plasma and aqueous humor as well as cognitive functions with pseudoexfoliation syndrome (PEX).

Methods: One-hundred forty-two patients with PEX have been included for this study; median age: 75 years (Q₁= 71,5; Q₃= 80,0). Control group comprised 93 subjects aged 74 years (Q₁= 68,0; Q₃= 80,0). Amyloid β-40 and β-42 (Aβ-40, Aβ-42) concentrations were assessed in plasma in 73 PEX patients and 49 controls. Aβ-40 concentration in aqueous humor was measured in 31 patients from each group. Mini Mental State Examination (MMSE) and Clock Drawing Tests were performed in 83 PEX patients and 36 controls.

Results: The differences between amyloid concentrations both in plasma and in aqueous humor in PEX and control groups were not statistically significant. There were no differences in MMSE and Clock Drawing Tests between groups.

Conclusion: Our results do not indicate any relation between PEX and Alzheimer’s amyloids or cognitive functions in cataract patients.

• Amyloid β-42
• amyloid β-40
• aqueous humor
• β cognitive functions
• plasma
• pseudoexfoliation

Declaration of interest

None of the authors has conflict of interest with this submission.

No financial support was received for this submission.