The effect of vitamin a supplementation on tear fluid retinol levels of marginally nourished preschool children

Eric J. van Agtmaal The Netherlands Ophthalmic Research institute, Biochemical Laboratory, P.O. Box 12141, 1100, AC, Amsterdam, The Netherlands

Martin W. Bloem NO-CIVO Toxicology and Nutrition institute, Department of Clinical Biochemistry, P.O. Box 360, 3700, AJ, Zeist, The Netherlands

Andries J. Speek NO-CIVO Toxicology and Nutrition institute, Department of Clinical Biochemistry, P.O. Box 360, 3700, AJ, Zeist, The Netherlands

Sastri Saowakontha Khon Kaen University, Faculty of Medicine, Khon Kaen, 40002, Thailand

Wil H.P. Schreurs NO-CIVO Toxicology and Nutrition institute, Department of Clinical Biochemistry, P.O. Box 360, 3700, AJ, Zeist, The Netherlands

Nicolaas J. van Haeringen The Netherlands Ophthalmic Research institute, Biochemical Laboratory, P.O. Box 12141, 1100, AC, Amsterdam, The Netherlands

Abstract

Vitamin A has been determined in tear fluid and blood plasma of marginally nourished Thai children before and after supplementation with a single, oral dose of 110 mg retinyl palmitate. After two months a significant rise of tear fluid retinol levels of the supplemented group was observed as compared to the non-supplemented group, while after four months no difference could be found. Determination of vitamin A levels in tear fluid may be useful in clinical eye research, with special regard to xerophthalmia.

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The effect of vitamin a supplementation on tear fluid retinol levels of marginally nourished preschool children

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The effect of vitamin a supplementation on tear fluid retinol levels of marginally nourished preschool children

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