Experimental autoimmune uveoretinitis: a model system for immunointervention: a review

J. V. Forrester Department of Ophthalmology, University of Aberdeen, Medical School, Foresterhill, Aberdeen, AB9 2ZD, UK

Janet Liversidge Department of Ophthalmology, University of Aberdeen, Medical School, Foresterhill, Aberdeen, AB9 2ZD, UK

H. S. Dua Department of Ophthalmology, University of Aberdeen, Medical School, Foresterhill, Aberdeen, AB9 2ZD, UK

A. Dick Department of Ophthalmology, University of Aberdeen, Medical School, Foresterhill, Aberdeen, AB9 2ZD, UK

Fiona Harper Department of Ophthalmology, University of Aberdeen, Medical School, Foresterhill, Aberdeen, AB9 2ZD, UK

P. G. McMenamin Department of Anatomy and Human Biology, University of Western Australia, Nedlands, Perth, Western Australia, 6009

Abstract

Experimental autoimmune uveoretinitis (EAU) is a useful model of human posterior uveitis and as such, permits the analysis of strategies for immuno-intervention. Modulation of the autoimmune response may be attempted at the stages of induction of EAU, during homing of autoreactive lymphocytes to the target organ, the retina, or during the effector stage of the disease. This paper presents a brief overview of current immuno-therapeutic modalities and assesses the usefulness for extrapolation to human disease.

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