Developmental expression of S-antigen in fetal human and rat eye

Ming Ni Laboratories of Immunology, National Eye Institute National Institutes of Health, Bethesda, MD, 20892, USA

Kunihiko Yamaki Retinal Cells and Molecular Biology, National Eye Institute National Institutes of Health, Bethesda, MD, 20892, USA

Takanobu Kikuchi Retinal Cells and Molecular Biology, National Eye Institute National Institutes of Health, Bethesda, MD, 20892, USA

Michael Ferrick Laboratories of Immunology, National Eye Institute National Institutes of Health, Bethesda, MD, 20892, USA

Toshimichi Shinohara Retinal Cells and Molecular Biology, National Eye Institute National Institutes of Health, Bethesda, MD, 20892, USA

Robert B. Nussenblatt Laboratories of Immunology, National Eye Institute National Institutes of Health, Bethesda, MD, 20892, USA

Chi-Chao Chan Laboratories of Immunology, National Eye Institute National Institutes of Health, Bethesda, MD, 20892, USA

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Abstract

Developmental expression of S-antigen and its mRNA in human and rat fetal retina was studied by immunocytochemical and in situ hybridization techniques. Immunocytochemistry indicated that S-antigen was present after 4 months gestation in the fetal human retina. In the rat, S-antigen was detected in the retina only after birth. In situ hybridization studies indicated that the S-antigen mRNA was present at 13 weeks gestational age in the human and at 15 days in the rat embryo. S-antigen mRNA was expressed not only in the retina but also in ocular tissues of neural crest origin in the fetus.

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Developmental expression of S-antigen in fetal human and rat eye

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Developmental expression of S-antigen in fetal human and rat eye

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