Effects of Irradiation and Inhibition of Adenosine Diphosphate Ribosyl Transferase in Radiation Sensitive and Resistant Mouse Lymphoma (L5178Y) Cells

K. J. Johanson THE NATIONAL DEFENCE RESEARCH INSTITUTE, S-901 82, UMEÅ; THE GUSTAF WERNER INSTITUTE, S-751 21, UPPSALA, SWEDEN; THE DEPARTMENT OF RADIATION BIOLOGY AND HEALTH PROTECTION, INSTITUTE OF NUCLEAR CHEMISTRY AND TECHNOLOGY, PL-03-195, WARSZAWA, POLAND

S. Sundell-Bergman THE NATIONAL DEFENCE RESEARCH INSTITUTE, S-901 82, UMEÅ; THE GUSTAF WERNER INSTITUTE, S-751 21, UPPSALA, SWEDEN; THE DEPARTMENT OF RADIATION BIOLOGY AND HEALTH PROTECTION, INSTITUTE OF NUCLEAR CHEMISTRY AND TECHNOLOGY, PL-03-195, WARSZAWA, POLAND

I. Szumiel THE NATIONAL DEFENCE RESEARCH INSTITUTE, S-901 82, UMEÅ; THE GUSTAF WERNER INSTITUTE, S-751 21, UPPSALA, SWEDEN; THE DEPARTMENT OF RADIATION BIOLOGY AND HEALTH PROTECTION, INSTITUTE OF NUCLEAR CHEMISTRY AND TECHNOLOGY, PL-03-195, WARSZAWA, POLAND

D. Wlodek THE NATIONAL DEFENCE RESEARCH INSTITUTE, S-901 82, UMEÅ; THE GUSTAF WERNER INSTITUTE, S-751 21, UPPSALA, SWEDEN; THE DEPARTMENT OF RADIATION BIOLOGY AND HEALTH PROTECTION, INSTITUTE OF NUCLEAR CHEMISTRY AND TECHNOLOGY, PL-03-195, WARSZAWA, POLAND

Abstract

The effects of treatment with benzarnide, an inhibitor of adenosine diphosphate (ADP) ribosyl transferase, were studied in two strains of L5178Y lymphoma cells of differential sensitivity to ionizing radiation. Continuous 2 rnmoYl benzamide treatment enhanced the killing effect of roentgen irradiation in the sensitive cells, but not in the resistent cells. Three hours' treatment with 2 to 15 mmoVl benzarnide sensitized irradiated cells of both strains to a similar extent. Rejoining of DNA breaks was delayed by 2 mmoVl benzamide in sensitive cells more than in resistant cells.

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Effects of Irradiation and Inhibition of Adenosine Diphosphate Ribosyl Transferase in Radiation Sensitive and Resistant Mouse Lymphoma (L5178Y) Cells

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Effects of Irradiation and Inhibition of Adenosine Diphosphate Ribosyl Transferase in Radiation Sensitive and Resistant Mouse Lymphoma (L5178Y) Cells

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