Local Anaesthetics Modifying the Dermal Response of Irradiation: An experimental study

L. Ohlsén Departments Of Plastic Surgery, Clinical Pathology, And Oncology, University Hospital, S-75185, Uppsala; Astra Alab Ab, Pain Control-Clinical Research, S-15185, Sodertalje, Sweden

H. Evers Departments Of Plastic Surgery, Clinical Pathology, And Oncology, University Hospital, S-75185, Uppsala; Astra Alab Ab, Pain Control-Clinical Research, S-15185, Sodertalje, Sweden

K. Segerstrom Departments Of Plastic Surgery, Clinical Pathology, And Oncology, University Hospital, S-75185, Uppsala; Astra Alab Ab, Pain Control-Clinical Research, S-15185, Sodertalje, Sweden

E. Hagelqvist Departments Of Plastic Surgery, Clinical Pathology, And Oncology, University Hospital, S-75185, Uppsala; Astra Alab Ab, Pain Control-Clinical Research, S-15185, Sodertalje, Sweden

S. Graffman Departments Of Plastic Surgery, Clinical Pathology, And Oncology, University Hospital, S-75185, Uppsala; Astra Alab Ab, Pain Control-Clinical Research, S-15185, Sodertalje, Sweden

Abstract

In a series of experiments in rabbits the dermal reaction, provoked by a single dose or intermittent doses of irradiation, was prevented or modified by topical or parenteral administration of local anaesthetics, compared to irradiated control animals. The topical application of a eutectic lidocaine/prilocaine cream, EMLA 5%, was found to be more effective than intravenously injected lidocaine (Xylocain 1%).

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Local Anaesthetics Modifying the Dermal Response of Irradiation: An experimental study

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Local Anaesthetics Modifying the Dermal Response of Irradiation: An experimental study

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