Development of functional specializations within the maturing rabbit flexor digitorum profundus tendon

Abstract

Along its length, the rabbit flexor digitorum profundus (FDP) tendon exhibits two functionally specialized regions: classical tendon (CT) and fibrocartilage (FC). We examined their development in rabbits, ranging in age from newborn to nine-months postnatal, using a combination of light microscopic, immunohistochemical and biochemical techniques.

There is little histodifferentiation in newborn tendon. Both regions are composed of thin collagenous fibers, numerous fibroblast-like cells and a low molecular weight dermatan-sulfate proteoglycan. Regional specialization has begun by two-weeks postnatal and by three-months postnatal, FC regions have been transformed into a true fibrocartilage characterized by a complex collagenous and elastic fiber network, numerous chondrocytes and a matrix rich in a high molecular weight predominantly chondroitin-sulfate proteoglycan and type II collagen. These features are elaborated between three and nine-months postnatal. CT regions undergo little substantial change during growth and maturation.

The rabbit is born altricial and incapable of adult patterns of locomotion. We propose that the developmental expression of functional specializations within the FDP tendon is closely linked with the onset of different physical demands arising from the adoption of adult patterns of locomotion.

Key Words:

• tendon
• development
• biomechanics
• proteoglycan