Hepatic Triglyceride and Lipoprotein Lipase Activities of Post-heparin Plasma in Normals and Hypertriglyceridemics

Jonas Boberg Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, California, USA

Merike Boberg Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, California, USA

Richard Gross Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, California, USA

John D. Turner Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, California, USA

Jan Augustin Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, California, USA

W. Virgil Brown Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, California, USA

Abstract

Post-heparin plasma hepatic triglyceride lipase (H-TGL) and lipoprotein lipase (LPL) activities were 8–34 and 3.5–21 (range) μmol/ml/hr respectively in males with normal serum lipid concentrations. In females the corresponding values were 4–25 and 4–16 μmol/ml/hr. No significant differences were observed between ages or between the two sexes.

Male patients with hypertriglyceridaemia had similar activities of H-TGL but significantly lower values for LPL activities than the control males.

Significant linear correlations were found between serum triglyceride concentrations and LPL activities both for males (coefficient of correlation = r = −0.64) and for females (r = −0.62).

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Hepatic Triglyceride and Lipoprotein Lipase Activities of Post-heparin Plasma in Normals and Hypertriglyceridemics

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Hepatic Triglyceride and Lipoprotein Lipase Activities of Post-heparin Plasma in Normals and Hypertriglyceridemics

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